IPython is an enhanced Python shell that does magic and is wonderful. Apart from me, everyone else uses it. You can install it with "easy_install IPython" on Windows, Linux, etc. Recent versions have a graphical console (start with "ipython-qtconsole") to which we can add some molecular eye candy. Greg Landrum has already done this for RDKit. Here's how to do it for Pybel.
First of all, here's the before picture:
Now, copy and paste the following into the console: